Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol

作者：Siddique Yasir Hasan^*; Ara Gulshan; Beg Tanveer; Afzal Mohammad

来源：Fitoterapia, 2010, 81(6): 590-594.

DOI：10.1016/j.fitote.2010.02.003

• Apigenin
• Ethinylestradiol
• Antigenotoxicity
• Natural plant products

In the present study the antigenotoxic effect of apigenin was studied against a genotoxic dose of ethinylestradiol using the damage parameters of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and cell cycle kinetics (CCK). Human peripheral blood lymphocytes were cultured and treated with 10 mu M of ethinylestradiol along with doses of 5, 10, 15 and 20 mu M of apigenin. A clear decrease in the genotoxic damage induced by ethinylestradiol was observed with increasing doses of apigenin, suggesting a protective role for apigenin during ethinylestradiol therapy.

• 出版日期2010-9