A novel benzofurazan-cyclam conjugate and its Cu(II) complex: Synthesis, characterization and in vitro cytotoxicity and antimicrobial activity

作者：Grabchev Ivo^*; Yordanova Stanislava; Vasileva Tonkova Evgenia; Cangiotti Michela; Fattori Alberto; Alexandrova Radostina; Stoyanov Stanimir; Ottaviani Maria Francesca^*

来源：Dyes and Pigments, 2016, 129: 71-79.

DOI：10.1016/j.dyepig.2016.02.013

• Benzofurazan
• Cyclam
• Copper complex
• Antimicrobial
• Cytotoxicity
• EPR
• Photophysical

A novel benzofurazan-cyclam conjugate and its Cu(II) complex have been synthesized and characterized. The photophysical properties have been investigated in organic solvents with different polarity. It has been found that the new compound is solvatochromic in nature. The biological activity of the resulting compounds was investigated to evaluate the effectiveness of these molecules as potential antimicrobial agents. The copper free ligand showed antibacterial and antifungal activity which increased after the formation of a copper complex. In contrast the cytotoxl icity against human Hela cervical carcinoma and human MDA-MB-231 breast cancer cells is more pronounced at the free ligand. The results suggest that the new compounds are promising for application in biomedicine in the design of new effective preparations.

• 出版日期2016-6