Diversification of the 3-benzazepine scaffold applying Ugi/reductive Heck sequence

作者：Peshkov Anatoly A; Peshkov Vsevolod A^*; Pereshivko Olga P; Van der Eycken Erik V

来源：Tetrahedron, 2015, 71(23): 3863-3871.

DOI：10.1016/j.tet.2015.04.022

• 3-Benzazepines
• Ugi reaction
• Reductive Heck reaction
• Diversity-oriented synthesis

A two step sequence involving Ugi reaction followed by reductive Heck cyclization has been evaluated in order to provide access to a 3-benzazepine framework in a diversity-oriented fashion. Several aspects related to the substrate scope and the optimal distribution of the required functional groups have been addressed, resulting in the construction of a small library of the title compounds, featuring four distinct types of substitution pattern.

• 出版日期2015-6-10
• 单位苏州大学