A Study of Alkylation Regioselectivity of 5-Substituted Tetrazoles with Chloroacetamides

作者:Pokhodylo N T*; Savka R D; Matiichuk V S; Obushak N D
来源:Russian Journal of General Chemistry, 2010, 80(4): 836-841.
DOI:10.1134/S1070363210040262

摘要

Alkylation of 5-aryltetrazoles with N-arylchloroacetamides commonly proceeds regioselectively at 2 position of the tetrazole ring. The ratio of 1,5- and 2,5-regioisomers depends on the nature of a substituents in the benzene ring of the N-arylchloroacetamide and position of a substituent in the aryltetrazole aryl group. Features of (1)H NMR spectra of the synthesized compounds are discussed.

  • 出版日期2010-4