Differential impact of juvenile stress and corticosterone in juvenility and in adulthood, in male and female rats

作者：Jacobson Pick Shlomit; Richter Levin Gal^*

来源：Behavioural Brain Research, 2010, 214(2): 268-276.

DOI：10.1016/j.bbr.2010.05.036

• Anxiety
• Affective disorder
• Animal model
• Early-onset

Depressive and anxiety symptoms experienced by children have often been attributed to normative age-related mood disturbances. In the last decade, early-onset of affective illness has been recognized as a major public health problem. The current study utilized exposure to juvenile stress, which was previously shown to have long-term effects into adulthood in male rats, to compare early to adulthood consequences of juvenile stress on anxiety indices and exploratory behavior in the open field and elevated plus maze. Furthermore, both male and female rats were examined, and in addition, the role of corticosterone as a potential mediator of some of these effects in juvenility and in adulthood, was assessed. Experiments 1-2 examined in male and female rats immediate and long-term behavioral effects of juvenile stress. Experiment 3 assessed circulating corticosterone (CURT) levels, and in experiment 4 male and female rats were injected i.p. with CURT, in either juvenility or in adulthood, to examine whether CURT could mimic the effects of juvenile stress. As expected, in adulthood, juvenile stress resulted in reduced exploratory behavior and reduced exploration of high-risk areas of the mazes. A similar pattern was found in both males and females. In contrast, a reversed behavioral pattern was found in juvenility in both male and female rats, although detailed differences were found between sexes. The application of CURT induced a similar reversed behavioral pattern in juvenile and adult rats of both sexes. Thus, the juvenile stress model might serve as an animal model for studying early-onset of affective illness.

• 出版日期2010-12-10