An in vitro study of the role of beta-boswellic acid in the microtubule assembly dynamics

作者：Karima Oveis; Riazi Gholamhossein^*; Khodadadi Sirus; Yousefi Reza; Mahnam Karim; Mokhtari Farzad; Cheraghi Tayebe; Hoveizi Elham; Moosavi Movahedi Ali Akbar

来源：FEBS LETTERS, 2012, 586(23): 4132-4138.

DOI：10.1016/j.febslet.2012.10.007

• Microtubule
• beta-Boswellic acid
• Assembly dynamic
• Critical concentration
• Molecular simulation

Structural integrity of microtubule protein (MTP) is pivotal for its physiological roles. Disruption of the MTP network is known to be involved in neurodegenerative disorders. The gum resin of plants of the boswellia species, with beta-boswellic acid (BBA) as the major component, has long been used in Ayurveda and Oriental Medicine to prevent amnesia. In the current study, we addressed the question whether BBA affects assembly dynamics behavior of tubulin. Our in vitro results revealed that BBA increases MTP length distribution and the polymerization rate of tubulin, moderately stabilizing it and diminishing both the critical concentration (C-c) and the fraction of inactive tubulin (F-i).

• 出版日期2012-11-30