A novel axially chiral phosphine-oxazoline ligand with an axis-unfixed biphenyl backbone: Preparation, complexation, and application in an asymmetric catalytic reaction

作者：Zhang, Wanbin^*; Xie, Fang; Yoshinaga, Hidefumi; Kida, Toshiyuki; Nakatsuji, Yohji; Ikeda, Isao

来源：Synlett, 2006, (8): 1185-1188.

DOI：10.1055/s-2006-933100

• P,N-ligands
• chiral biaryl ligands
• oxazoline ligands
• axial chirality
• palladium-catalyzed allylic alkylation

A novel chiral phosphine-oxazoline ligand 3 with an, axis-unfixed biphenyl backbone was prepared. This ligand existed as a mixture of two diastereomers in equilibrium in solution. However, when it was coordinated with palladium(II), only one of the two kinds of possible diastereomer complexes with different axial chirality was formed. When this axis-unfixed chiral ligand was used, up to 90% ee was attained for the palladium-catalyzed asymmetric allylic alkylation.

• 出版日期2006-5-15
• 单位上海交通大学