Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

作者：Zamani Mohammad Reza; A**agh Firouzeh Akbari; Massoud Amir Hossein; Salmaninejad Arash; Massoud Ahmad; Rezaei Nima^*

来源：Journal of Assisted Reproduction and Genetics, 2015, 32(1): 103-106.

DOI：10.1007/s10815-014-0371-4

• PD-1
• Polymorphism
• Antisperm antibodies
• Infertility

Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signalling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. This study investigates PD-1 gene polymorphism in patients with antisperm antibody-related infertility
Genotyping was performed by polymerase chain reaction and restriction enzyme digestion (PCR-RFLP), this polymorphism was genotyped in 145 Iranian subjects (61 patients with antisperm antibody-related infertility and 84 healthy controls).
Patients frequencies of the G/A genotype in comparison with healthy controls (38.2 % vs. 32.7 %, OR =1.21, P = 0.35) were not significantly different. However, G/G and A/A genotype frequencies between patients and healthy controls were significantly different (P = 0.042, P = 0.00001, respectively). Also, allele frequencies of this polymorphism were significantly different (P = 0.0012) in patients compared to healthy controls.
According to these results, there is a correlation between PD-1 gene polymorphism and susceptibility to antisperm antibody-related infertility in our study group.

• 出版日期2015-1