Neurocognition with maraviroc compared with tenofovir in HIV

作者：Robertson Kevin R; Miyahara Sachiko; Lee Anthony; Brown Todd T; Chan Ellen S; Berzins Baiba; Rusin David; Eron Joseph J; Taiwo Babafemi O

来源：AIDS, 2016, 30(15): 2315-2321.

DOI：10.1097/QAD.0000000000001189

• central nervous system
• HIV-associated neurocognitive disorders
• maraviroc
• neurocognitive
• neuropathogenesis
• tenofovir

Objective: The objective was to determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART).
Design: Randomized, double-blind, placebo-controlled, 48-week trial.
Setting: Participants were enrolled in US AIDS Clinical Trials Group clinical trial sites.
Participants: Total 262 ART-naive, chemokine coreceptor 5 tropic HIV, and HIV RNA greater than 1000 copies/ml participants were randomized, 230 participants completed the study.
Intervention: Participants received MVC 150 mg or tenofovir disoproxil fumarate (TDF) 300mg on a background of ritonavir-boosted darunavir and emtricitabine.
Main outcome measure(s): The neuropsychological battery of 15 tests done at baseline, week 24 and week 48 assessed seven domains, and were standardized into z-scores then converted into deficit scores and a global deficit score. The 48-week changes from baseline in the neuropsychological scores and the global deficit score were compared by Wilcoxon or Kruskal-Wallis test between arms, and among baseline impairment groups [classified as normal, mild (2 deficit scores >= 1) and moderate (2 deficit scores >= 2)]. It was hypothesized that the MVC arm would have improved neuropsychological performance over TDF.
Results: In this double-blind, randomized, placebo-controlled trial, there were no differences in neuropsychological performance between MVC and TDF. Those with moderate neuropsychological impairment at baseline experienced greater ART-mediated neuropsychological improvement than those with mild or no neuropsychological impairment.
Conclusion: Improvement in neurocognitive functioning was greater with more baseline impairment but was comparable with MVC or TDF.

• 出版日期2016-9-24
• 单位西北大学