Diagnostic value of PIVKA-II in detecting hepatocellular carcinoma in Chinese patients with hepatitis B virus infection

作者：Tang, Xiao-Qiong; Li, Hong; Yan, Li-Bo; Zhou, Ling-Yun; Chen, En-Qiang; Liu, Miao; Zhang, Dong-Mei; Tang, Hong^*

来源：Future Virology, 2017, 12(5): 259-267.

DOI：10.2217/fvl-2017-0017

• hepatocellular carcinoma
• hepatitis B virus
• prothrombin induced by vitamin K absence-II

Evaluation of prothrombin induced by vitamin K absence-II (PIVKA-II) in detecting hepatitis B virus-associated hepatocellular carcinoma (HCC). Materials & methods: PIVKA-II and AFP levels were measured in 366 Chinese subjects (176 HCC, 98 liver cirrhosis and 92 noncirrhotic chronic hepatitis B patients). Results: PIVKA-II showed a sensitivity of 82.4% and a specificity of 95.9% at a cut-off value of 40.5 mAU/ml versus 73.9 and 82.9% for AFP at a cut-off value of 12.3 ng/ml for differentiating HCC from non-HCC. In detecting small-sized HCC (<3 cm), the sensitivity of PIVKA-II, AFP and their combination was 63.6, 75.8 and 84.8%, respectively. Conclusion: PIVKA-II was more efficient than AFP in detecting HBV-associated HCC, and their combination could improve the detection sensitivity.

• 出版日期2017-5
• 单位四川大学