Competition and boundary formation in heterogeneous media: Application to neuronal differentiation

作者：Perthame Benoit; Quininao Cristobal^*; Touboul Jonathan

来源：Mathematical Models and Methods in Applied Sciences, 2015, 25(13): 2477-2502.

DOI：10.1142/S0218202515400151

• Morphogen gradients
• reaction-diffusion systems
• traveling waves
• asymptotic analysis
• boundary formation

We analyze an inhomogeneous system of coupled reaction-diffusion equations representing the dynamics of gene expression during differentiation of nerve cells. The outcome of this developmental phase is the formation of distinct functional areas separated by sharp and smooth boundaries. It proceeds through the competition between the expression of two genes whose expression is driven by monotonic gradients of chemicals, and the products of gene expression undergo local diffusion and drive gene expression in neighboring cells. The problem therefore falls in a more general setting of species in competition within a nonhomogeneous medium. We show that in the limit of arbitrarily small diffusion, there exists a unique monotonic stationary solution, which splits the neural tissue into two winner-takes-all parts at a precise boundary point: on both sides of the boundary, different neuronal types are present. In order to further characterize the location of this boundary, we use a blow-up of the system and define a traveling wave problem parametrized by the position within the monotonic gradient: the precise boundary location is given by the unique point in space at which the speed of the wave vanishes.

• 出版日期2015-12-15
• 单位INRIA