Association study of CCND1 G870A polymorphism with gastric cancer risk: evidence from a meta-analysis

作者：Wang Xiufeng; Cao Li; Zhang Fangxin; Wang Xiuli; Zhang Jiucong; Pei Juhong; Kong Dehua

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(2): 1644-1651.

• CCND1
• polymorphism
• gastric cancer
• meta-analysis

Background: The correlation between CCND1 G870A polymorphism with gastric cancer risk had studied by teams of researchers widely, but the results were inconsistent. It is necessary to conduct a meta-analysis for exploring whether really existed a relevance between them with previous studies. Methods: Electronic searching of PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), WanFang and Weipu databases was conducted for all eligible studies. And seven publications including 1,583 cases and 2,491 controls were finally collected into this meta-analysis. The heterogeneity among studies was detected by chi-square-based Q-test. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated by the fixed or random effect model for all genetic models to evaluate the effect of CCND1 G870A polymorphism on gastric cancer. Begg's funnel plot and Egger's linear regression were used to do check whether existed publication bias. Results: The overall result showed that CCND1 G870A polymorphism had no significant relevance with gastric cancer (OR=1.05, 95% CI=0.91-1.22). But a subgroup analysis by control source, CCND1 G870A polymorphism was associated with a moderate increase risk of gastric cancer only in population-based group under the model of AA vs. GA + GG (OR=1.25, 95% CI=1.02-1.53). Conclusion: This meta-analysis indicates that CCND1 G870A polymorphism with AA genotype may play a certain role in the etiology of gastric cancer.

• 出版日期2016
• 单位中国人民解放军兰州军区兰州总医院