Size-dependent multispectral photoacoustic response of solid and hollow gold nanoparticles

作者：Gutrath Benjamin S^*; Beckmann Martin F; Buchkremer Anne; Eckert Thomas; Timper Jan; Leifert Annika; Richtering Walter; Schmitz Georg; Simon Ulrich

来源：Nanotechnology, 2012, 23(22): 225707.

DOI：10.1088/0957-4484/23/22/225707

Photoacoustic (PA) imaging attracts a great deal of attention as an innovative modality for longitudinal, non-invasive, functional and molecular imaging in oncology. Gold nanoparticles (AuNPs) are identified as superior, NIR-absorbing PA contrast agents for biomedical applications. Until now, no systematic comparison of the optical extinction and PA efficiency of water-soluble AuNPs of various geometries and small sizes has been performed. %26lt;br%26gt;Here spherical AuNPs with core diameters of 1.0, 1.4 and 11.2 nm, nanorods with longitudinal/transversal elongation of 38/9 and 44/12 nm and hollow nanospheres with outer/inner diameters of 33/19, 57/30, 68/45 and 85/56 nm were synthesized. The diode laser set-up with excitations at 650, 808, 850 and 905 nm allowed us to correlate the molar PA signal intensity with the molar extinction of the respective AuNPs. Deviations were explained by differences in heat transfer from the particle to the medium and, for larger particles, by the scattering of light. The molar PA intensity of 1.0 nm AuNPs was comparable to the commonly used organic dye methylene blue, and rapidly increased with the lateral size of AuNPs.

• 出版日期2012-6-8