Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury

作者：White Nathan J; Wang Yi; Fu Xiaoyun; Cardenas Jessica C; Martin Erika J; Brophy Donald F; Wade Charles E; Wang Xu; St John Alexander E; Lim Esther B; Stern Susan A; Ward Kevin R; Lopez Jose A; Chung Dominic

来源：Free Radical Biology and Medicine, 2016, 96: 181-189.

DOI：10.1016/j.freeradbiomed.2016.04.023

• Oxidative stress
• Fibrinogen
• Coagulopathy
• Methionine sulfoxide
• Hemorrhage
• Trauma

Victims of trauma often develop impaired blood clot formation (coagulopathy) that contributes to bleeding and mortality. Fibrin polymerization is one critical component of clot formation that can be impacted by post-translational oxidative modifications of fibrinogen after exposure to oxidants. In vitro evidence suggests that A alpha-C domain methionine sulfoxide formation, in particular, can induce conformational changes that prevent lateral aggregation of fibrin protofibrils during polymerization. We used mass spectrometry of plasma from trauma patients to find that fibrinogen A alpha-C domain methionine sulfoxide content was selectively-increased in patients with coagulopathy vs. those without coagulopathy. This evidence supports a novel linkage between oxidative stress, coagulopathy, and bleeding after injury.

• 出版日期2016-7