Amphetamine Induced Dopamine Release Increases Anxiety in Individuals Recovered from Anorexia Nervosa

作者：Bailer Ursula F; Narendran Rajesh; Frankle W Gordon; Himes Michael L; Duvvuri Vikas; Mathis Chester A; Kaye Walter H^*

来源：International Journal of Eating Disorders, 2012, 45(2): 263-271.

DOI：10.1002/eat.20937

• anorexia nervosa
• amphetamine
• dopamine
• anxiety
• positron emission tomography

Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. %26lt;br%26gt;Method: We used an amphetamine challenge and positron emission tomography [C-11]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW). %26lt;br%26gt;Results: REC AN and CW were similar for baseline, postamphetamine [C-11]raclopride binding potential (BPND) and change (Delta) in BPND for all regions. In CW, ventral striatum Delta BPND was associated with euphoria (r = -0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Delta BPND in the precommissural dorsal caudate (r = -0.62, p = 0.05). %26lt;br%26gt;Discussion: REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants.

• 出版日期2012-3