Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan

作者：Matsunaga Takuya; Yamashita Kiyoshi; Kubuki Yoko; Toyama Takanori; Imataki Osamu; Maeda Kouichi; Kawano Noriaki; Satou Seiichi; Kawano Hiroshi; Ishizaki Junzo; Yoshida Shuro; Kameda Takuro; Sasaki Tadashi; Sekine Masaaki; Kamiunten Ayako; Taniguchi Yasuhiro; Hidaka Tomonori; Katayose Keiko; K Shimoda Haruko; Shide Kotaro; Yamamoto Shojiro; Moritake Hiroshi; Nunoi Hiroyuki; Makino Shigeyoshi; Kitanaka Akira; Matsuoka Hitoshi; Shimoda Kazuya

来源：International Journal of Hematology, 2012, 96(3): 342-349.

DOI：10.1007/s12185-012-1146-2

• Acute myeloid leukemia (AML)
• Population-based study
• Clinical practice

We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acute promyelocytic leukemia (APL), the proportion of patients with myelodysplasia, unfavorable risk karyotypes, antecedent hematologic diseases, prior chemotherapy for other malignancies, and small proportion of blasts in the marrow was higher in patients a parts per thousand yen65 years, and patients with poor performance status (PS) and higher WBC counts at diagnosis were more prevalent among patients a parts per thousand yen75 years. One-third of the adult non-APL patients met the inclusion criteria usually applied in clinical trials: de novo AML, age a parts per thousand currency sign64 years with PS 0-2 and no key organ dysfunction. The 5-year overall survival (OS) rate of adult non-APL patients was 21.1 % (patients a parts per thousand currency sign64 years, 33.8 %; 65-74 years, 21.6 %; a parts per thousand yen75 years, 0 %). Multivariate analysis revealed that French-American-British subtypes M0, M6, and M7, poor PS (3, 4), unfavorable risk karyotypes, and higher WBC counts at diagnosis were independent adverse prognostic factors associated with OS. This analysis provides real world data.

• 出版日期2012-9