Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases

作者：Ge Jingyan; Cheng Xiamin; Tan Lay Pheng; Yao Shao Q^*

来源：Chemical Communications, 2012, 48(37): 4453-4455.

DOI：10.1039/c2cc31294h

The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs)that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates.

• 出版日期2012