Acute administration of GLP-1 receptor agonists induces hypolocomotion but not anxiety in mice

作者：Krass Maarja; Ruenkorg Kertu; Vasar Eero; Volke Vallo^*

来源：Acta Neuropsychiatrica, 2012, 24(5): 296-300.

DOI：10.1111/j.1601-5215.2012.00648.x

• anxiety
• cortisol
• neuroendocrinology
• stress

Krass M, Runkorg K, Vasar E, Volke V. Acute administration of GLP-1 receptor agonists induces hypolocomotion but not anxiety in mice. Objective: The aim of this study was to compare the behavioural and hormonal effects of systemic (subcutaneous) treatment with glucaemically equipotent doses of exenatide and liraglutide in mice. Methods: The effects of glucagon-like peptide-1 (GLP-1) receptor agonists were determined on anxiety level in the lightdark compartment test, the motor activity in automated activity cages and finally the forced swimming test was performed. Results: Both exenatide (120 mu g/kg) and liraglutide (2001200 mu g/kg) decreased the glucose levels up to 30% in freely fed animals. In glucaemically equipotent doses the drugs induced very similar behavioural and hormonal effects: there was no change on anxiety level or immobility time, however, both drugs suppressed motor activity and increased corticosterone levels. Conclusion: We conclude that the two clinically approved GLP-1 receptor agonists induce very similar suppression of motor activity and stimulation of corticosterone release in mice.

• 出版日期2012-10