Mitochondria-targeting "Nanoheater" for enhanced photothermal/chemo-therapy

作者：Chen, Si; Lei, Qi; Qiu, Wen-Xiu; Liu, Li-Han; Zheng, Di-Wei; Fan, Jin-Xuan; Rong, Lei; Sun, Yun-Xia^*; Zhang, Xian-Zheng^*

来源：Biomaterials, 2017, 117: 92-104.

DOI：10.1016/j.biomaterials.2016.11.056

• Gold nanostar
• Mitochondria-targeting
• Photothermal therapy
• Combination therapy
• Pro-apoptotic peptide

In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R-8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also introduced via electrostatic interaction to obtain a versatile nanoplatform AuNS-pep/DOX@HA. It was found that the nanoplatform could be internalized into tumor cells via CD44 receptor-mediated recognition. Followed digestion by hyaluronidase (HAase), the therapeutic nanoplatform was able to release DOX for chemotherapy and mitochondria-targeting nanoheater AuNS-pep for near infrared (NIR) light triggered subcellular photothermal therapy (PTT). This tumor-targeting nanoplatform AuNS-pep/DOX@HA displayed prominent non-resistant or resistant tumor inhibition both in vitro and in vivo.

• 出版日期2017-2
• 单位武汉大学; 武汉工程大学