Wheat Allergens Associated With Baker's Asthma

作者：Salcedo G^*; Quirce S; Diaz Perales A

来源：Journal of Investigational Allergology and Clinical Immunology, 2011, 21(2): 81-92.

• Baker's asthma
• Wheat allergens
• Component-resolved diagnosis
• alpha-amylase/trypsin inhibitors
• Nonspecific lipid transfer protein
• Prolamin

Baker's asthma is a frequent occupational allergic disease caused mainly by inhalation of cereal flour, particularly wheat flour. This review deals with the current diagnosis and immunomodulatory treatments, as well as the role of wheat allergens as molecular tools to enhance management and knowledge of this disease. The review also discusses the current status of several salt-soluble proteins (albumins and globulins)-cereal alpha-amylase/trypsin inhibitors, peroxidase, thioredoxin, nonspecific lipid transfer protein, serine proteinase inhibitor, and thaumatin-like protein as well as salt-insoluble storage proteins (prolamins, namely, gliadins and glutenins) as allergens associated with baker's asthma. Finally, current limitations to using these proteins as molecular tools for diagnosis and immunotherapy are highlighted.

• 出版日期2011