Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs

作者：Lee Jangwoo; Choi Kyungho; Park Jeongim; Moon Hyo Bang; Choi Gyuyeon; Lee Jeong Jae; Suh Eunsook; Kim Hai Joong; Eun So Hee; Kim Gun Ha; Cho GeumJoon; Kim Sung Koo^*; Kim Sungjoo^*; Kim Su Young^*; Kim Seunghyo^*; Eom Soyong; Choi Sooran; Kim Young Don; Kim Sungkyoon^*

来源：Science of the Total Environment, 2018, 626: 1494-1501.

DOI：10.1016/j.scitotenv.2017.10.042

• Bisphenol A
• Pregnant women
• Neonates
• Tissue distribution
• BPA ratio

Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios inmother-neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318mother-neonate pairs at six university hospitals in Korea. BPA levelswere detected using liquid chromatography tandemmass spectrometry. The ratios of the BPA levels in the other sample types to the levels in maternal serumwere calculated. BPA was detected in 79.5-100% of the maternal and fetal samples. The median BPA concentration in the samples decreased in the order of neonatal urine (4.75 ng/mL), maternal urine (2.86 ng/mL), cord serum(1.71 ng/mL), maternal serum (1.56 ng/mL), breast milk (0.74 ng/mL), and the placenta (0.53 ng/g). We estimated the ratios of BPA levels in the other sample types to those in maternal serum. The median (95th percentile) cord serum-to-maternal serum ratio was 1.12 (15.2) for 160 mother-fetal pairs, in which BPA was detected in both samples. The placenta-, maternal urine-, neonatal urine-, and breast milk-tomaternal serum ratios were 0.28 (5.31), 1.79 (29.9), 1.98 (28.2), and 0.51 (10.5), respectively. In addition, the median (95th percentile) cord serum-to-placenta ratio was 4.03 (45.8), and the neonatal urine-to-cord serum ratio was 1.95 (25.6). The 95th percentile values were 14-20-fold greater than the medians. Urine contained the highest BPA concentrations, followed by serum, breast milk, and the placenta. The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus.

• 出版日期2018-6-1