A network of interorganellar communications underlies cellular aging

作者：Leonov Anna; Titorenko Vladimir I^*

来源：IUBMB Life, 2013, 65(8): 665-674.

DOI：10.1002/iub.1183

• cellular aging
• interorganellar communications
• signaling network of cellular aging
• biomolecular networks of cellular aging
• an endomembrane system governing cellular aging
• cell-autonomous mechanisms of organismal aging
• mitochondria
• lysosomes and vacuoles
• peroxisomes

Organelles within a eukaryotic cell respond to age-related intracellular stresses and environmental factors by altering their functional states to generate, direct and process the flow of interorganellar information that is essential for establishing a pro- or antiaging cellular pattern. i.e., organelle-organelle and organelle-cytosol) communications regulate cellular aging in evolutionarily distant eukaryotes. Our analysis suggests a model for an intricate network of intercompartmental communications that underly cellular aging in eukaryotic organisms across phyla. This proposed model posits that the numerous directed, coordinated and regulated organelle-organelle and organelle-cytosol communications integrated into this network define the long-term viability of a eukaryotic cell and, thus, are critical for regulating cellular aging.

• 出版日期2013-8