AN EFFICIENT SYNTHESIS OF 3-(ARYLSULFANYL)QUINOLIN-4(1H)-ONES VIA CYCLIZATION OF N-12-[2-(ARYLSULFANYL)ACETYL)PHENYL)BENZAMIDES WITH N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL

作者：Kobayashi Kazuhiro^*; Nishikawa Kohei; Nogi Takashi

来源：Heterocycles, 2016, 92(12): 2225-2234.

DOI：10.3987/COM-16-13566

The reaction of N-42-(2-chloroacetyl)phenyl]benzamides, readily derived from 2-(2,2-dichloroethenyl)benzenamines, with sodium arenethiolates gives the corresponding N-{2{2-(arylsulfanyl)acetyliphenyllbenzamides. These are treated with N,N-dimethylformaide dimethyl acetal (DMF-DMA) to yield 3-(arylsulfanyl)quinolin-4(1H)-ones in generally good yields.

• 出版日期2016-12-1