New insights into the catalytic reduction of aliphatic nitro compounds with hypophosphites under ultrasonic irradiation

作者：Letort S; Lejeune M; Kardos N; Metay E; Popowycz F; Lemaire M; Draye M^*

来源：Green Chemistry, 2017, 19(19): 4583-4590.

DOI：10.1039/c7gc01622k

This work describes an efficient process for the reduction of nitro compounds to the corresponding amines with a catalytic amount of Pd/C (0.6 mol%), and a mixture of sodium hypophosphite and hypophosphorous acid as a reducing agent in H2O/2-MeTHF at 60 degrees C. The reaction was optimized under silent conditions. The conditions for the in situ production of H-2 using the mixture NaH2PO2/H3PO2 were studied. The influence of ultrasonic activation was investigated both in terms of efficiency and kinetics. The reaction was shown to be efficient in water, at 70 degrees C with a quantitative conversion and a maximal yield in only 15 min thanks to the ultrasonic activation. Finally, ultrasound was proved to act as a physical agent of phase transfer.

• 出版日期2017-10-7