Determination of Propylthiouracil in Pharmaceuticals by Differential Pulse Voltammetry Using a Cathodically Pretreated Boron-Doped Diamond Electrode

作者：Sartori Elen Romao; Trench Aline Barrios; Rocha Filho Romeu C; Fatibello Filho Orlando

来源：Journal of the Brazilian Chemical Society, 2013, 24(9): 1504-1511.

DOI：10.5935/0103-5053.20130190

• propylthiouracil determination
• 6-propyl-2-thiouracil
• BDD electrode
• cathodic pretreatment
• differential pulse voltammetry

A simple procedure is described for the determination of propylthiouracil (PTU) by differential pulse voltammetry (DPV) using a cathodically pretreated boron-doped diamond (BDD) electrode. Cyclic voltammetry studies indicate that the oxidation of PTU is irreversible at a peak potential of 1.42 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized conditions, the obtained analytical curve was linear (r = 0.9985) for the PTU concentration range of 1.0 to 29.1 mu mol L-1 in a BR buffer solution (pH 2.0), with a detection limit of 0.90 mu mol L-1. The proposed method was successfully applied in the determination of PTU in pharmaceutical samples, with results in agreement at a 95% confidence level with those obtained using an official titration method.

• 出版日期2013-9