Antral Follicle Count Is Increased in Obese Women Placed on Oral Contraceptive Pills

作者：Parker April K; Grindler Natalia M; Jungheim Emily S; Odem Randall R; Ratts Valerie S; Cooper Amber R^*

来源：Journal of Reproductive Medicine, 2015, 60(3-4): 155-159.

• antral follicle count
• BMI
• body mass index
• in vitro fertilization
• infertility
• IVF
• obesity
• ovarian suppression

OBJECTIVE: To determine the effect of short-term combined oral contraceptive (OCP) use on antral follicle count (AFC) in obese and nonobese women with infertility.
STUDY DESIGN: A retrospective review of women who had an AFC (sum of 2-10 mm- bilateral ovarian follicles on basal follicular phase ultrasound) measured before and after short-term OCP use between the years 2005 and 2010. These were women who had a baseline AFC measurement during an unsuccessful controlled ovarian hyperstimulation/intrauterine insemination who were then placed on OCPs prior to an in vitro fertilization (IVF) cycle that included a subsequent AFC measurement at baseline.
RESULTS: A total of 57 IVF cycles met criteria for inclusion in the study. AFC was not impacted by OCP use in the nonobese cohort (BMI < 30). Baseline AFC in obese women (BMI >= 30), however, increased after OCP use (18 +/- 6 vs. 28 +/- 9, p = 0.002).
CONCLUSION: Use of suppressive medications like OCPs in obese women increases AFC during IVF, potentially by AFC cohort synchrony. This observation warrants consideration when using AFC to predict gonadotropin/ART response as well as future prospective research to further elucidate potential etiologies.

• 出版日期2015-4