Assessment of cytotoxicity and toxicity for phosphonium-based deep eutectic solvents

作者：Hayyan Maan^*; Hashim Mohd Ali; Al Saadi Mohammed A; Hayyan Adeeb; AlNashef Inas M; Mirghani Mohamed E S

来源：Chemosphere, 2013, 93(2): 455-459.

DOI：10.1016/j.chemosphere.2013.05.013

• Deep eutectic solvent
• Ionic liquid
• Cytotoxicity
• Toxicity
• Anti-bacteria
• Brine shrimp

In this work, the cytotoxicity and toxicity of phosphonium-based deep eutectic solvents (DESs) with three hydrogen bond donors, namely glycerine, ethylene glycol, and triethylene glycol were investigated. The cytotoxicity effect was tested using brine shrimp (Artemia sauna). The toxicity was investigated using the two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity of tested DESs was much higher than that of their individual components, indicating their toxicological behavior was different. It was also found that there was toxic effect on the studied bacteria, indicating their potential application as anti-bacterial agents. To the best of our knowledge, this is the first time the cytotoxicity and toxicity of phosphonium-based DESs were studied.

• 出版日期2013-9