Allele polymorphisms of interleukin-10 and hepatitis B, C virus infection

作者：Lu Yong-liang; Wu Xiao; Huang Hui-lian; Dai Li-cheng^*

来源：Chinese Medical Journal, 2010, 123(10): 1338-1344.

DOI：10.3760/cma.j.issn.0366-6999.2010.10.021

• meta-analysis
• interleukin-10
• hepatitis B virus
• hepatitis C virus

Background Interleukin 10 (IL-10) is an important cytokine with anti-inflammatory, anti-immune and anti-fibrotic functions. This study aimed at evaluating the relationship between allele polymorphisms in the IL-10 promoter region and hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
Methods The odds ratios (ORs) of IL-10 allele distributions in patients with HBV or HCV infection were analyzed against healthy controls. All the relevant studies in PubMed were identified, and poor qualified studies were excluded. The meta-analysis software REVMAN 4.2 was applied for investigating heterogeneity among individual studies and summarizing all the studies. The publication bias was also evaluated.
Results This study demonstrated a significant association between the IL-10-592 A/C polymorphism and HBV infection in the Asian population under the overall effect size of allele A versus C. In our subgroup meta-analysis, we found a significant association of IL-10-592 A/C polymorphism to HCV infection susceptibility in Asian populations, although sensitivity analysis showed that the combined result was not associated with the worldwide population. Other IL-10 allele polymorphisms were not associated with HBV or HCV infection.
Conclusion IL-10-592 NC allele might be a risk factor for HBV or HCV in Asians but not in Europeans. Chin Med J 2010;123(10):1338-1344

• 出版日期2010-5-20
• 单位湖州师范学院