Muscle CARs and TcRs: turbo-charged technologies for the (T cell) masses

作者：Kalos Michael^*

来源：Cancer Immunology, Immunotherapy, 2012, 61(1): 127-135.

DOI：10.1007/s00262-011-1173-5

• Chimeric antigen receptor
• T cell receptor
• Adoptive T cell transfer
• Immunotherapy
• Gene transfer
• CIMT 2011

A central role for T cells in the control of cancer has been supported by both animal models and clinical observations. Accordingly, the development of potent anti-tumor T cell immunity has been a long-standing objective of immunotherapy. Emerging data from clinical trials that test T cell immune-modulatory agents and genetically engineered and re-targeted T cells have begun to realize the profound potential of T cell immunotherapy to target cancer. This review will focus on a description of recent conceptual and technological advances for the genetic engineering of T cells to enhance anti-tumor T cell immunity through the introduction of tumor-specific receptors, both Chimeric Antigen Receptors (CAR) and T cell receptors (TcR), as well as an overview of emerging data from ongoing clinical trials that highlight the potential of these approaches to effect dramatic and potent antitumor immunity.

• 出版日期2012-1