GTPase regulation: Getting aRnd rock and Rho inhibition

作者：Chardin P^*

来源：Current Biology, 2003, 13(18): R702-R704.

DOI：10.1016/S0960-9822(03)00645-6

Rnd proteins are atypical members of the Rho small G protein family that inhibit the formation of actomyosin contractile fibers via activation of RhoGAPs and inhibition of a Rho effector, the Ser/Thr kinase Rock. These mechanisms might be used to fine-tune Rho GTPase inhibition locally at sites where particular actin structures need to be made.

• 出版日期2003-9-16