Development and Characterizations of a Miniature Capillary Electrophoresis Mass Spectrometry System

作者：He Muyi; Xue Zhenhua; Zhang Yinna; Huang Zejian; Fang Xiang; Qu Feng; Ouyang Zheng; Xu Wei^*

来源：Analytical Chemistry, 2015, 87(4): 2236-2241.

DOI：10.1021/ac504868w

A miniature capillary electrophoresis mass spectrometry (CE/MS) system has been developed in this work. A 100% electrical driven miniaturized CE device was integrated with a miniature MS instrument, which has a discontinuous atmospheric pressure interface (DAPI) for coupling with atmospheric pressure ionization sources. A nanoelectrospray ionization (nano-ESI) source was developed with a sheath liquid interface for coupling the miniature CE and the MS system. A systematic characterization and optimization of the analytical performance have been done. The analysis of isobaric peptides and avoiding charge competition effects in nano-ESI sources have been demonstrated.

• 出版日期2015-2-17
• 单位北京理工大学; 中国计量科学研究院