Functional Nanogels as Platforms for Imparting Antibacterial, Antibiofilm, and Antiadhesion Activities to Stainless Steel

作者：Faure Emilie^*; Falentin Daudre Celine; Lanero Tiziana Svaldo; Vreuls Christelle; Zocchi Germaine; Van De Weerdt Cecile; Martial Joseph; Jerome Christine; Duwez Anne Sophie; Detrembleur Christophe

来源：Advanced Functional Materials, 2012, 22(24): 5271-5282.

DOI：10.1002/adfm.201201106

• functional coatings
• cross-linking
• nanogels
• antibacterial coatings
• antibiofilm coatings

In this work, long-term antibacterial, antiadhesion, and antibiofilm activities are afforded to industrial stainless steel surfaces following a green and bio-inspired strategy. Starting from catechol bearing synthetic polymers, the film cross-linking and the grafting of active (bio)molecules are possible under environmentally friendly conditions (in aqueous media and at room temperature). A bio-inspired polyelectrolyte, a polycation-bearing catechol, is used as the film-anchoring polymer while a poly(methacrylamide)-bearing quinone groups serves as the cross-linking agent in combination with a polymer bearing primary amine groups. The amine/quinone reaction is exploited to prepare stable solutions of nanogels in water at room temperature that can be easily deposited to stainless steel. This coating provides quinone-functionalized surfaces that are then used to covalently anchor active (bio)molecules (antibiofilm enzyme and antiadhesion polymer) through thiol/quinone reactions.

• 出版日期2012-12-19