Nanoplasmonic smooth silica versus porous calcium carbonate bead biosensors for detection of biomarkers

作者：Yashchenok Alexey M; Borisova Dimitriya; Parakhonskiy Bogdan V; Masic Admir; Pinchasik Bat El; Moehwald Helmuth; Skirtach Andre G^*

来源：Annalen der Physik, 2012, 524(11): 723-732.

DOI：10.1002/andp.201200158

• Nanoplasmonic
• biomarkers
• beads
• Raman
• calcium carbonate
• porous
• SERS

Nanoplasmonic biosensors based on gold nanoparticle functionalized smooth silica and porous calcium carbonate particles are presented. It is identified in this comparative study the role of porosity for adsorbing gold nanoparticles and subsequent detection of biomarkers. That is further applied in this study for detection of biomarkers. Detection of glucose a biomarker of diabetes is studied together with that of bovine serum albumin a very relevant bio-molecule. Raman scattering is used for label-free detection of molecules in the sub-mu MmM range detection capabilities, which covers the range corresponding to healthy and diseased persons. Implications of current study for detection and identification of biomarkers are discussed.

• 出版日期2012-11