Allergen Specific Immunoglobulin E in Children Under 6 Years Old With Total Immunoglobulin E Below 10 kU/L

作者：Topic Renata Zrinski^*; Dodig Slavica; Zivcic Jadranka; Raos Miljenko

来源：Laboratory Medicine, 2011, 42(3): 158-160.

DOI：10.1309/LMIAKW2Z09FGQBFK

• allergy
• children
• hypersensitivity
• immunoglobulin E
• screening

Objective: This study assesses the rate of allergen specific immunoglobulin E (sIgE) antibody positive findings in children under 6 years old with total immunoglobulin E (tIgE) concentrations below 10 kU/L as well as the relationship between sIgE concentrations and other diagnostic parameters.
Methods: In vitro and in vivo findings were retrospectively analyzed in 193 children.
Results: There were significant differences in serum tIgE concentrations and peripheral blood eosinophil granulocyte counts between the groups of children with positive and negative sIgE findings. Negative skin prick tests were found in 54% of children with positive sIgE findings.
Conclusions: We suggest that sIgE concentrations be determined in children under 6 years old irrespective of tIgE concentrations if an allergy is indicated by clinical symptoms. Blood sampling for immunoglobulin E (IgE) determination should preferably be performed during the period of allergen exposure. Timely detection of sensitization is crucial to identify children at an increased risk of allergic disease.

• 出版日期2011-3