科研之友
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摘要
A number of podophyllotoxin derivatives were analyzed by AMI method. Some information from the calculation results and the inhibition of L-1210 indicate that there are three structurally distinct domains:The C-4 position is an effective modified point. The B ring and E ring are important active centers. The results also show that the hole of positive charge in B ring easily combines with an acceptor within the molecule. The E ring along with its C-4' xyl group is an important center of negative electricity.
- 出版日期2001-4
- 单位中山大学
