Massive introgression drives species radiation at the range limit of Anopheles gambiae

作者：Vicente Jose L; Clarkson Christopher S; Caputo Beniamino; Gomes Bruno; Pombi Marco; Sousa Carla A; Antao Tiago; Dinis Joao; Botta Giordano; Mancini Emiliano; Petrarca Vincenzo; Mead Daniel; Drury Eleanor; Stalker James; Miles Alistair; Kwiatkowski Dominic P; Donnelly Martin J; Rodrigues Amabelia; della Torre Alessandra; Weetman David; Pinto Joao

来源：Scientific Reports, 2017, 7(1): 46451.

DOI：10.1038/srep46451

Impacts of introgressive hybridisation may range from genomic erosion and species collapse to rapid adaptation and speciation but opportunities to study these dynamics are rare. We investigated the extent, causes and consequences of a hybrid zone between Anopheles coluzzii and Anopheles gambiae in Guinea-Bissau, where high hybridisation rates appear to be stable at least since the 1990s. Anopheles gambiae was genetically partitioned into inland and coastal subpopulations, separated by a central region dominated by A. coluzzii. Surprisingly, whole genome sequencing revealed that the coastal region harbours a hybrid form characterised by an A. gambiae-like sex chromosome and massive introgression of A. coluzzii autosomal alleles. Local selection on chromosomal inversions may play a role in this process, suggesting potential for spatiotemporal stability of the coastal hybrid form and providing resilience against introgression of medically-important loci and traits, found to be more prevalent in inland A. gambiae.

• 出版日期2017-4-18