Association Between Estrogen Receptor Gene Polymorphism and Back Pain Intensity in Female Patients With Degenerative Lumbar Spondylolisthesis

作者：Roh Hyoung Lok; Lee Jung Sub^*; Suh Kuen Tak; Kim Jeung Il; Lee Hong Seok; Goh Tae Sik; Park Shi Hwan

来源：Journal of Spinal Disorders & Techniques, 2013, 26(2): E53-E57.

DOI：10.1097/BSD.0b013e318260a09c

• degenerative spondylolisthesis
• estrogen receptor alpha
• polymorphism

Study Design: Prospective study.
Objective: To examine the possible association of estrogen receptor alpha (ER alpha) polymorphisms and pain intensity in symptomatic female degenerative spondylolisthesis (DS) patients.
Summary of Background Data: DS has been associated with a significant sex effect. Thus, several studies about the association between the ER gene and osteoarthritis have been reported. However, whether estrogen is associated with pain sensitivity is inconsistent in the existing literatures from both human and animal studies.
Methods: The PvuII and XbaI polymorphisms, bone mineral density at the lumbar spine (LSBMD) and at the femoral neck (FNBMD), pain intensity at the leg and lower back, and radiologic and anthropometric findings were analyzed in 192 patients with DS.
Results: There was a significant association between XbaI polymorphism and the visual analog scale score of back pain. The back pain visual analog scale in patients with a GG genotype was significantly higher than in patients with the AG (P < 0.05) or the AA (P < 0.05) genotypes. In addition, the presence of the CG haplotype was found to be associated with back pain intensity in the haplotype analysis of the PvuII and the XbaI polymorphisms of ER alpha.
Conclusions: These results suggest that the ER alpha gene polymorphism using XbaI restriction enzyme influences the perception of back pain in patients with DS.

• 出版日期2013-4