Long-term administration of escitalopram in patients with social anxiety disorder in Japan

作者：Asakura Satoshi^*; Hayano Taiji; Hagino Atsushi; Koyama Tsukasa

来源：Neuropsychiatric Disease and Treatment, 2016, 12: 1817-1825.

DOI：10.2147/NDT.S108983

• escitalopram
• Japanese
• long-term study
• social anxiety disorder
• selective serotonin reuptake inhibitors

Purpose: To investigate the safety, tolerability, and effectiveness of escitalopram in patients with social anxiety disorder in Japan.
Methods: A 52-week, open-label study was conducted in Japanese patients with social anxiety disorder with a total score >= 60 on the Liebowitz Social Anxiety Scale - Japanese Version (LSAS-J) and >= 4 on the Clinical Global Impression - Severity Scale. Escitalopram 10 mg/day was administered for the first week and could be increased to 20 mg/day.
Results: The study included 158 patients: 81.0% (128/158) completed 52 weeks of escitalopram treatment, 68.4% (108/158) increased their dose to 20 mg/day, and 56.3% (89/158) remained on 20 mg/day. Adverse drug reactions were reported by 57.6% (91/158) of patients. The most common (incidence >= 10%) were somnolence and nausea. The incidence of adverse drug reactions was similar in extensive and poor metabolizers of cytochrome P450 2C19. No adverse drug reactions increased in incidence by >5% after week 12. The incidence of serious adverse events was 1.3% (2/158). No deaths occurred. The LSAS-J total scores improved until week 52. The LSAS-J response rate (>= 30% improvement in LSAS-J) was 69.0%, the Clinical Global Impression - Improvement Scale response rate (<= 2) was 73.0%, and the LSAS-J remission rate (<= 30) was 27.0%.
Conclusion: In this first 52-week clinical study of social anxiety disorder, escitalopram 10-20 mg/day was safe, well tolerated, and effective in Japanese patients.

• 出版日期2016