Design and synthesis of palladium (II) OCO pincer type complexes and their catalytic role towards the α-arylation of ketones

作者：Kai, Wang; Qian, Hua^*; Liu, Dabin; Ye, Zhiwen

来源：Journal of Saudi Chemical Society, 2019, 23(3): 274-283.

DOI：10.1016/j.jscs.2018.07.004

• alpha-Arylation
• Ketones
• Aryl halides
• Pd-pincer complexes
• Catalysis

Twelve OCO bisacetamide ligands 4aa-4dc were synthesized after condensation of isophenylenediamines 1a-1d and anhydride/acyl chlorides. The corresponding Pd(II)-OCO-H (5aa-5ac), Pd(II)-OCO-Me(5ba-5bc), Pd(H)-OCO-OMe(5ca-5cc), Pd(H)-OCO-NO2(5da-5dc) pincer complexes were prepared via C-H activation of precursors and Pd(OAc)(2), and characterized by IR, H-1 NMR, C-13 NMR and elemental analysis. The st-arylation of ketones and aryl bromides catalyzed by 5 under low catalyst loadings (0.1 mol%) show that 5da exhibits the highest catalytic activity, resulting in a 98% isolated yield.

• 出版日期2019-3
• 单位南京理工大学