AMP-activated protein kinase: a therapeutic target in intestinal diseases

作者：Sun Xiaofei; Zhu Mei Jun

来源：Open Biology, 2017, 7(8): 170104.

DOI：10.1098/rsob.170104

• AMPK
• absorption
• barrier function
• colorectal cancer
• intestinal health
• intestinal inflammation

Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions. This review summarizes the favourable outcomes of AMPK activation on intestinal health, and discusses AMPK as a potential therapeutic target for intestinal diseases.

• 出版日期2017-8