Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy

作者：Camelo Serge; Lavelette Sophie; Guillonneau Xavier; Raoul William; Sennlaub Florian^*

来源：Ophthalmologica, 2016, 236(1): 53-58.

DOI：10.1159/000446587

• Interleukin-17
• Lymphocytes
• CD3
• Choroid
• Geographic atrophy
• Age-related macular degeneration

Purpose: To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA). Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age matched control donors. Results/Conclusion: We showed that IL-17(+) cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17+ cells mainly localized to CD3(+) cells, which identifies T lymphocytes, as well as IBA-1(+) cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.

• 出版日期2016