Alcohol Consumption, Serum Gamma-Glutamyltransferase, and Helicobacter Pylori Infection in a Population-Based Study Among 9733 Older Adults

作者：Gao, Lei^*; Weck, Melanie N.; Stegmaier, Christa; Rothenbacher, Dietrich; Brenner, Hermann

来源：Annals of Epidemiology, 2010, 20(2): 122-128.

DOI：10.1016/j.annepidem.2009.11.009

• Alcoholic Beverage
• Alcohol Consumption
• Gamma-Glutamyltransferase
• Helicobacter pylori
• Population-Based

PURPOSE: Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GOT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study.
METHODS: In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GOT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire.
RESULTS: A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GOT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers.
CONCLUSIONS: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori. Ann Epidemiol 2010;20:122-128.

• 出版日期2010-2
• 单位中国医学科学院北京协和医院; 北京协和医学院