The use and midium-term evaluation of decellularized allograft cusp in the surgical treatment of the Tetralogy of Fallot

作者：Mulinari Leonardo Andrade^*; Navarro Fabio Binhara; Pimentel Gustavo Klug; Miyazaki Silvia Midori; Binotto Cristine Nogueira; Pelissari Eliana Costa; Miyague Nelson Itiro; Affonso Da Costa Francisco Diniz

来源：Brazilian Journal of Cardiovascular Surgery, 2008, 23(2): 197-203.

DOI：10.1590/S0102-76382008000200008

• Tetralogy of Fallot/surgery
• Heart defects, congenital
• Treatment outcome
• Child
• Follow-up studies
• Transplantation, homologous

Objective: To describe the technique of implantation and to show the echocardiographic follow-up of the decellularized cusps allografts used in patients with Tetralogy of Fallot.
Methods: Fifteen patients underwent this implantation between March 2005 and August 2007 and they were clinically followed-up. An echocardiogram was performed to evaluate the morphofunctional result of the allografts.
Results: The mean follow-up was 12.7 months (1-25 months). The echocardiography results showed that pulmonary insufficiency was mild in nine (60%) patients, moderate in three (20%) patients, and severe in three (20%) patients. The results also showed that the systolic right ventricle function was normal in 13 (86.7%) and that there was mild dysfunction in two (13.3%). Eleven (73.4%) patients did not present any gradient in the right ventricular outflow tract and four (26.6%) presented mild stenosis. The mobility of the cusps were normal in all cases and there was no thickness larger than 1,5mm. There was no calcification; 14 patients (93,3%) presented Z score between -1 and 0,7 and one patient presented dilated pulmonary annulus with a Z score of + 2.5.
Conclusion: In midium-term follow-up, the decellularized allograft seemed to be a good option for right ventricle outflow tract enlargement in patients underwent Tetralogy of Fallot.

• 出版日期2008-6