Activation of innate immune antiviral responses by Nod2

作者：Sabbah Ahmed; Chang Te Hung; Harnack Rosalinda; Frohlich Victoria; Tominaga Kaoru; Dube Peter H; Xiang Yan; Bose Santanu^*

来源：Nature Immunology, 2009, 10(10): 1073-U49.

DOI：10.1038/ni.1782

Pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization domain 2 (Nod2) can also function as a cytoplasmic viral PRR by triggering activation of interferon-regulatory factor 3 (IRF3) and production of interferon-beta (IFN-beta). After recognition of a viral ssRNA genome, Nod2 used the adaptor protein MAVS to activate IRF3. Nod2-deficient mice failed to produce interferon efficiently and showed enhanced susceptibility to virus-induced pathogenesis. Thus, the function of Nod2 as a viral PRR highlights the important function of Nod2 in host antiviral defense mechanisms.

• 出版日期2009-10