A Paradox: alpha-Klotho Levels and Smoking Intensity

作者：Verde Zoraida^*; Rodriguez Gonzalez Moro Jose M; Chicharro Luis M; Reinoso Barbero Luis; Bandres Fernando; Gomez Gallego Felix; Santiago Catalina

来源：Lung, 2017, 195(1): 53-57.

DOI：10.1007/s00408-016-9944-6

• Healthy smokers
• alpha-Klotho
• Aging
• Packs year smoked
• Cigarettes per day

Reports regarding smoking differences in alpha-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule alpha-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble alpha-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that alpha-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of alpha-klotho might be a compensatory response to smoking stress in healthy population.

• 出版日期2017-2