Delayed substantia nigra damage and leukoencephalopathy after hypoxic-ischemic injury

作者：Lou, Min; Jing, Chao-hui; Selim, Magdy H.; Caplan, Louis R.; Ding, Mei-ping^*

来源：Journal of the Neurological Sciences, 2009, 277(1-2): 147-149.

DOI：10.1016/j.jns.2008.09.032

• Anoxia
• Hypoxia
• Delayed encephalopathy
• Substantia nigra
• Leukoencephalopathy
• Anemia

Delayed post-anoxic encephalopathy has rarely been reported, and has most commonly been associated with carbon monoxide poisoning. The underlying pathophysiological mechanism is unknown. We describe a patient with a delayed neurologic decline after a good initial recovery from a hypoxic-ischemic event precipitated by acute blood loss. MRI revealed early globus pallidus necrosis followed by delayed substantia nigra damage and leukoencephalopathy. We suggest that anemia might play a role in this pattern of hypoxic-ischemic brain injury.

• 出版日期2009-2-15
• 单位浙江大学