An Efficient Two-Step Synthesis of New 5-Substituted-1H-tetrazoles of Biological Interest

作者:Zanatta Nilo*; da Silva Fabio M; da Silva Andreia M P W; Aquino Estefania da C; Bonacorso Helio G; Martins Marcos A P
来源:Journal of Heterocyclic Chemistry, 2013, 50(4): 868-873.
DOI:10.1002/jhet.1711

摘要

A simple procedure for the synthesis and characterization of new 3-alkoxy-3-(1H-tetrazol-5-yl)propionic acids and 2-(1H-tetrazol-5-yl)tetrahydrofuran- and -(1H-tetrazol-5-yl)-2H-pyran-3-carboxylic acids from the [2+3] cycloaddition reactions between the nitrile group of -cyanocarboxylic acids with sodium azide in the presence of zinc chloride is described. The tetrazolic acids were isolated in moderate to good yields and are structurally analogous to succinic acid.

  • 出版日期2013-7

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