Arg(972) insulin receptor substrate-1 polymorphism and risk and severity of rheumatoid arthritis

作者：Zhao, Hongjun; Liu, Shiqing; Long, Mei; Peng, Lijuan; Deng, Hongxiang; You, Yunhui^*

来源：International Journal of Rheumatic Diseases, 2016, 19(2): 141-145.

DOI：10.1111/1756-185X.12366

• disease activity score of 28 joints (DAS28)
• gene polymorphism
• insulin receptor substrate-1
• insulin resistance
• rheumatoid arthritis

Aim: To explore the association between the Arg(972) insulin receptor substrate (IRS)-1 polymorphism (rs1801278) and the risk and disease activity/severity of rheumatoid arthritis (RA).
Method: We genotyped the Arg(972) IRS-1 polymorphism in 871 pairs of age-, sex-, body mass index-, residence area- and current smoking status-matched RA patients and controls. We assessed RA severity using the disease activity score of 28 joints (DAS28).
Results: The AA (homozygous Arg(972) IRS-1) and GA (heterozygous Arg(972) IRS-1) genotypes were significantly associated with high risk of RA with or without adjustment for comorbidities (P < 0.001). The A allele was significantly associated with high risk of RA (P < 0.001). The AA genotype was significantly associated with high/severe RA activity (P < 0.001), while the GG genotype (wild type IRS-1) had protective effects.
Conclusion: The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of RA, and therefore may be a potential prognostic factor for RA. This study adds novel insights into the pathogenesis of RA.

• 出版日期2016-2
• 单位中南大学