Modiolide and Pyrone Derivatives from the Sea Fan-derived Fungus Curvularia sp PSU-F22

作者：Trisuwan Kongkiat; Rukachaisirikul Vatcharin^*; Phongpaichit Souwalak; Preedanon Sita; Sakayaroj Jariya

来源：Archives of Pharmacal Research, 2011, 34(5): 709-714.

DOI：10.1007/s12272-011-0502-8

• Curvularia sp.
• Sea fan-derived fungus
• Modiolide
• Pyrone
• Mycoepoxydiene
• Antibacterial activity
• Antifungal activity

Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). Their antimicrobial activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus and Microsporum gypseum SH-MU-4 were examined.

• 出版日期2011-5