A novel strategy for the synthesis of enzymatically stable biotin-DOTA conjugates for in vivo use

作者：Turhanen Petri A^*; Weisell Janne; Lehtolainen Dalkilic Pauliina; Maatta Ann Marie; Vepsalainen Jouko; Narvanen Ale

来源：Medchemcomm, 2011, 2(9): 886-888.

DOI：10.1039/c1md00111f

Two In-111 radiolabelled biotin-DOTA conjugates were prepared containing an enzymatically stable amine bond (-CH2-NH-CH2-). Syntheses are straightforward and molecules were labelled with high radiochemical purity. They were also found to be stable in human plasma. This strategy provides a method to produce a simple biotin derivative not requiring any additional protection groups against biotinidase.

• 出版日期2011-9